Tenascin Supports Lymphocyte Rolling

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tenascin Supports Lymphocyte Rolling

Tenascin is a large extracellular matrix molecule expressed at specific sites in the adult, including immune system tissues such as the bone marrow, thymus, spleen, and T cell areas of lymph nodes. Tenascin has been reported to have both adhesive and anti-adhesive effects in static assays. We report here that tenascin supports the tethering and rolling of lymphocytes and lymphoblastic cell line...

متن کامل

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rolling. In contrast, alpha 4 (CD49d) integrins are shown here to initiate lymphocyt...

متن کامل

a4 Integrins Mediate Lymphocyte Attachment and Rolling under Physiologic Flow

C. Berlin, 1 R. F. Bargatze, 1, 2 j . j . Campbell,1 U. H. von Andrian, 1,3 M. C. Szabo, ~ S. R. Hasslen, 4 R. D. Nelson, 5 E. L. Berg, ~,8 S. L. Erlandsen, 7 and E. C. Butcher ~ 1Laboratory of Immunology and Vascular Biology Department of Pathology Stanford University Stanford, California 94305 and the Center for Molecular Biology and Medicine Foothill Research Center Veterans Affairs Medical ...

متن کامل

Transferrin-independent iron uptake supports B lymphocyte growth.

Raji, a malignant B-lymphocyte cell line containing Epstein-Barr virus genomic elements, has been conditioned to proliferate optimally in transferrin (Tf)-free medium containing a very low concentration of an iron salt. We provide evidence that an Tf-independent iron uptake system is physiologically important for maintaining the growth of these cells. The data show that Raji cells take up iron ...

متن کامل

Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling.

Lymphocyte homing to lymph nodes is regulated by transient but specific interactions between lymphocytes and high endothelial venules (HEVs), the initial phase of which is mainly governed by the leukocyte adhesion molecule L-selectin, which recognizes sulfated and sialylated O-linked oligosaccharides displayed on sialomucin core proteins. One of the sialomucin proteins, endomucin, is predominan...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1997

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.137.3.755